Kevin Kane, PhD
Dept. of Medical Microbiology & Immunology
University of Alberta
Faculty of Medicine & Dentistry
6-60A Heritage Medical Research Centre
T6G 2S2 Edmonton, AB
Ph : (780) 492-4997
Fx : (780) 492-9828
- Professor, Dept. of Medical Microbiology & Immunology
- Member of the ImmuNet Council
- Member Li Ka-shing Institute of Virology
The main research focus of my laboratory is to understand how CTL and NK cells recognize tumor cells or virally infected cells to destroy them and offer resistance to these challenges. Killer cell recognition appears to involve many complex receptor-ligand interactions between the killer cell and tumor cell surfaces. We take many complementary approaches in our research to study the function of killer cell receptors to determine the structural requirements and functional consequences of receptor engagement. A primary focus has been delineating the function of class I major histocompatibility complex (MHC) proteins, the central players in CTL and NK cell regulation. Our goal is to develop sufficient understanding of killer lymphocyte regulation to enhance mobilization of effective innate immunity and rationally design vaccines to stimulate adaptive T cell immunity to counter viral infections and cancer.
Inflammation of mouse lung during influenza infection
- Dr. Gang Zhou (Research Associate)
PLoS One. 2015 Jul 6;10(7):e0131308. doi: 10.1371/journal.pone.0131308. eCollection 2015.
Select item 24797174 3.
Ma BJ, Craveiro Salvado CM, Kane KP.
Immunogenetics. 2014 Aug;66(7-8):467-77. doi: 10.1007/s00251-014-0777-2. Epub 2014 May 7.
Zhou G, Juang SW, Kane KP.
Eur J Immunol. 2013 Apr;43(4):929-38. doi: 10.1002/eji.201242620. Epub 2013 Mar 6.
Ewen CL, Kane KP, Bleackley RC.
Mol Immunol. 2013 Jul;54(3-4):309-18. doi: 10.1016/j.molimm.2012.12.020. Epub 2013 Jan 23.
Ma BJ, Kane KP.
J Immunol. 2011 Sep 15;187(6):3267-76. doi: 10.4049/jimmunol.1002809. Epub 2011 Aug 12.