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MMI Faculty

Kevin Kane, PhD

Kane
Dept. of Medical Microbiology & Immunology
University of Alberta
Faculty of Medicine & Dentistry
6-60A Heritage Medical Research Centre
T6G 2S2 Edmonton, AB
Canada

Ph : (780) 492-4997
Fx : (780) 492-9828
Em: kevin.kane@ualberta.ca

 

 

Positions:

  • Professor, Dept. of Medical Microbiology & Immunology
  • Member of the ImmuNet Council
  • Member Li Ka-shing Institute of Virology

 

Research:

The main research focus of my laboratory is to understand how CTL and NK cells recognize tumor cells or virally infected cells to destroy them and offer resistance to these challenges. Killer cell recognition appears to involve many complex receptor-ligand interactions between the killer cell and tumor cell surfaces. We take many complementary approaches in our research to study the function of killer cell receptors to determine the structural requirements and functional consequences of receptor engagement. A primary focus has been delineating the function of class I major histocompatibility complex (MHC) proteins, the central players in CTL and NK cell regulation. Our goal is to develop sufficient understanding of killer lymphocyte regulation to enhance mobilization of effective innate immunity and rationally design vaccines to stimulate adaptive T cell immunity to counter viral infections and cancer.

 

Image

 

Inflammation of mouse lung during influenza infection

 

 

 

 

 

 

People:

  • Dr. Gang Zhou (Research Associate)

 

Publications:

Click here for most recent publications

 

Selected Publications:

 

PLoS One. 2015 Jul 6;10(7):e0131308. doi: 10.1371/journal.pone.0131308. eCollection 2015.

Identities of P2 and P3 Residues of H-2Kb-Bound Peptides Determine Mouse Ly49C Recognition. Marquez EA1, Kane KP1.

http://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=26147851

Select item 24797174 3.

The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.

Ma BJ, Craveiro Salvado CM, Kane KP.

Immunogenetics. 2014 Aug;66(7-8):467-77. doi: 10.1007/s00251-014-0777-2. Epub 2014 May 7.

NK cells exacerbate the pathology of influenza virus infection in mice.

Zhou G, Juang SW, Kane KP.

Eur J Immunol. 2013 Apr;43(4):929-38. doi: 10.1002/eji.201242620. Epub 2013 Mar 6.

PMID:

Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation.

Ewen CL, Kane KP, Bleackley RC.

Mol Immunol. 2013 Jul;54(3-4):309-18. doi: 10.1016/j.molimm.2012.12.020. Epub 2013 Jan 23.

PMID:

Recognition of class I MHC by a rat Ly49 NK cell receptor is dependent on the identity of the P2 anchor amino acid of bound peptide.

Ma BJ, Kane KP.

J Immunol. 2011 Sep 15;187(6):3267-76. doi: 10.4049/jimmunol.1002809. Epub 2011 Aug 12.

PMID:

21841133